Treatment of chronic myelogenous leukemia (CML) or as part of marrow ablation conditioning before bone marrow transplant (interferes with DNA alkylation).
Children: (for CML remission) 0.06–0.12 mg/kg/24 hr; titrate dose to keep leukocyte count > 40,000/mm3;(for bone marrow transplant conditioning) 1 mg/kg/dose q 6 hr for 16 doses.
Adults: (for CML remission) 0.06 mg/kg/24 hr

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